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Annexin A2 (ANX A2): An emerging biomarker and potential therapeutic target for aggressive cancers

20 Aug 2018

Abstract excerpt

) and phospholipids. ANX A2 plays an important role in many biological processes such as endocytosis, exocytosis, autophagy, cell-cell communications and biochemical activation of plasminogen. On the cell surface ANX A2 organizes the assembly of plasminogen (PLG) and tissue plasminogen activator (tPA) for efficient conversion of PLG to plasmin, a serine protease. Proteolytic activity of plasmin is required for...

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PMID: 30125343
DOI: 10.1002/ijc.31817

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