Article
Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.
Acta crystallographica. Section F, Structural biology communications - 1 Aug 2015
Baum Bernhard, Lecker Laura S M, Zoltner Martin, Jaenicke Elmar, Schnell Robert, Hunter William N, Brenk Ruth
Abstract excerpt
Bacterial infections remain a serious health concern, in particular causing life-threatening infections of hospitalized and immunocompromised patients. The situation is exacerbated by the rise in antibacterial drug resistance, and new treatments are urgently sought. In this endeavour, accurate st...
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