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Article

A bidomain nonribosomal peptide synthetase encoded by FUM14 catalyzes the formation of tricarballylic esters in the biosynthesis of fumonisins.

Biochemistry - 28 Feb 2006

Zaleta-Rivera Kathia, Xu Chunping, Yu Fengan, Butchko Robert A E, Proctor Robert H, Hidalgo-Lara María E, Raza Ashraf, Dussault Patrick H, Du Liangcheng

Abstract excerpt

Fumonisins are a group of polyketide-derived mycotoxins produced by Fusarium verticillioides, a filamentous fungus infecting corn and contaminating food and feeds. Fumonisins contain two tricarballylic esters that are critical for toxicity. Here, we present genetic and biochemical data for the esterification mechanism. FUM14 in F. verticillioides has been deleted by homologous recombination, and the resultant...

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PMID: 16489749
DOI: 10.1021/bi052085s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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