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Article

A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004

Portevin Damien, De Sousa-D'Auria Célia, Houssin Christine, Grimaldi Christine, Chami Mohamed, Daffé Mamadou, Guilhot Christophe

Abstract excerpt

Mycolic acids are major and specific constituents of the cell envelope of Corynebacterineae, a suborder of bacterial species including several important human pathogens such as Mycobacterium tuberculosis, Mycobacterium leprae, or Corynebacterium diphtheriae. These long-chain fatty acids are involved in the unusual architecture and impermeability of the cell envelope of these bacteria. The condensase, the enzyme...

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Identifiers

PMID: 14695899
DOI: 10.1073/pnas.0305439101
PMCID: PMC314182

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