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Article

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.

Blood - 28 Apr 2011

Zhou Qing, Munger Meghan E, Veenstra Rachelle G, Weigel Brenda J, Hirashima Mitsuomi, Munn David H, Murphy William J, Azuma Miyuki, Anderson Ana C, Kuchroo Vijay K, Blazar Bruce R

Abstract excerpt

Tumor-associated immune suppression can lead to defective T cell-mediated antitumor immunity. Here, we identified a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia (AML). This phenotype is characterized by the coexpression of Tim-3 and PD-1 on CD8(+) T cells...

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Source

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Identifiers

PMID: 21385853
DOI: 10.1182/blood-2010-10-310425
PMCID: PMC3099570

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21385853-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.PMID 21385853Read ↗

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