Acetate kinase isozymes confer robustness in acetate metabolism.

doi:10.1371/journal.pone.0092256

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Article

Acetate kinase isozymes confer robustness in acetate metabolism.

PloS one - 1 Jan 2014

Chan Siu Hung Joshua, Nørregaard Lasse, Solem Christian, Jensen Peter Ruhdal

Abstract excerpt

Acetate kinase (ACK) (EC no: 2.7.2.1) interconverts acetyl-phosphate and acetate to either catabolize or synthesize acetyl-CoA dependent on the metabolic requirement. Among all ACK entries available in UniProt, we found that around 45% are multiple ACKs in some organisms including more than 300 species but surprisingly, little work has been done to clarify whether this has any significance. In an attempt to gain...

Topics

Acetate Kinase
Acetates
Acetyl Coenzyme A
Base Sequence
Conserved Sequence
Genes, Bacterial
Isoenzymes
Kinetics
Lactic Acid
Lactococcus lactis
Maltose
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phylogeny

Pyruvic Acid

Sequence Homology, Amino Acid

Species Specificity

Terminator Regions, Genetic

Source

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Identifiers

PMID: 24638105
DOI: 10.1371/journal.pone.0092256
PMCID: PMC3956926

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