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YiaC and CobB regulate lysine lactylation in Escherichia coli

4 Nov 2022

Abstract excerpt

Lysine lactylation (Kla) has recently been reported to participate in regulating transcription in human cells. However, the characterization, regulatory mechanism and functional consequence of Kla in prokaryotes remain unclear. Here, we report that YiaC functions as a lysine lactylase and that CobB serves as a lysine delactylase in the regulation of metabolism. We demonstrate that YiaC catalyzes the addition of...

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PMID: 36333310
DOI: 10.1038/s41467-022-34399-y

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