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Article

Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.

Science (New York, N.Y.) - 19 Feb 2010

Wang Qijun, Zhang Yakun, Yang Chen, Xiong Hui, Lin Yan, Yao Jun, Li Hong, Xie Lu, Zhao Wei, Yao Yufeng, Ning Zhi-Bin, Zeng Rong, Xiong Yue, Guan Kun-Liang, Zhao Shimin, Zhao Guo-Ping

Abstract excerpt

Lysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes is largely unknown. We demonstrated that central metabolism enzymes in Salmonella were acetylated extensively and differentially in response to different carbon sources, concomitantly with changes in cell growth and metabolic flux. The relative activities of key enzymes controlling the direction of glycolysis versus...

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Identifiers

PMID: 20167787
DOI: 10.1126/science.1179687
PMCID: PMC4183141

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Source receipt: pubmed, retrieved 7 Sept 2026.

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