Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli.

Abstract excerpt

The Escherichia coli isocitrate dehydrogenase (ICDH) is one of the tricarboxylic acid cycle enzymes, playing key roles in energy production and carbon flux regulation. E. coli ICDH was the first bacterial enzyme shown to be regulated by reversible phosphorylation. However, the effect of lysine acetylation on E. coli ICDH, which has no sequence similarity with its counterparts in eukaryotes, is still unclear....

Topics

• Acetylation
• Crystallography, X-Ray
• Escherichia coli
• Escherichia coli Proteins
• Genetic Code
• Isocitrate Dehydrogenase