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Article

Effects of Genetic Polymorphisms of WNT Signaling Pathway on the Prognosis of Acute Lymphoblastic Leukemia in Chinese Pediatric Population.

Journal of pediatric hematology/oncology - 1 Jul 2025

Wen Xiaojia, Gao Chao, Li Weijing, Zhang Yuanyuan, Xue Tianlin, Cui Lei, Qi Peijing, Lin Wei, Li Jun, Li Zhigang, Wu Ying, Yu Jiaole, Zhang Ruidong, Zheng Huyong, Liu Shuguang

Abstract excerpt

The deregulation of WNT signaling has been shown to be important in the development of hematologic malignancies. The genetic variation of key WNT signaling pathway genes may affect the development of leukemia. In the present study, a total of 20 single nucleotide polymorphisms (SNPs) in 6 genes ( CTNNB1, AXIN2, SFRP2, SFRP4, SFRP5 , and DKK3 ) involved in the WNT signaling pathway were selected to investigate the...

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Identifiers

PMID: 40479595
DOI: 10.1097/MPH.0000000000003037

Genes

AXIN2
SFRP4
CTNNB1
DKK3
SFRP2
SFRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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