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Article

Evaluating the effect of mutations and ligand binding on transthyretin homotetramer dynamics.

PloS one - 1 Jan 2017

Saldaño Tadeo E, Zanotti Giuseppe, Parisi Gustavo, Fernandez-Alberti Sebastian

Abstract excerpt

Native transthyretin (TTR) homotetramer dissociation is the first step of the fibrils formation process in amyloid disease. A large number of specific point mutations that destabilize TTR quaternary structure have shown pro-amyloidogenic effects. Besides, several compounds have been proposed as drugs in the therapy of TTR amyloidosis due to their TTR tetramer binding affinities, and therefore, contribution to its...

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Identifiers

PMID: 28704493
DOI: 10.1371/journal.pone.0181019
PMCID: PMC5509292

Genes

TTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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