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Article

The pH-dependent stability of wild-type and mutant transthyretin oligomers.

Biophysical journal - 1 May 2003

Skoulakis S, Goodfellow J M

Abstract excerpt

A reduction in pH is known to induce the disassociation of the tetrameric form of transthyretin and favor the formation of amyloid fibers. Using continuum electrostatic techniques, we calculate the titration curves and the stability of dimer and tetramer formation of transthyretin as a function of pH. We find that the tetramer and the dimer become less stable than the monomer as the pH is lowered. The free energy...

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Identifiers

PMID: 12719214
DOI: 10.1016/S0006-3495(03)70009-5
PMCID: PMC1302845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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