Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-throughput detection of clinically targetable alterations using next-generation sequencing.

Oncotarget - 20 Jun 2017

Vendrell Julie A, Grand David, Rouquette Isabelle, Costes Valérie, Icher Samira, Selves Janick, Larrieux Marion, Barbe Aurore, Brousset Pierre, Solassol Jérôme

Abstract excerpt

Next-generation sequencing (NGS) has revolutionized the therapeutic care of patients by allowing high-throughput and parallel sequencing of large numbers of genes in a single run. However, most of available commercialized cancer panels target a large number of mutations that do not have direct therapeutic implications and that are not fully adapted to low quality formalin-fixed, paraffin-embedded (FFPE) samples....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Neoplasm
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Melanoma

Share to Molecular Diagnostic Techniques

Share to Molecular Targeted Therapy

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 28404952
DOI: 10.18632/oncotarget.15875
PMCID: PMC5522202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-throughput detection of clinically targetable alterations using next-generation sequencing.PMID 28404952Read ↗

Next-Generation Sequencing for the Identification of Targetable Molecular Alterations in Cancer.Semantic proximity Read ↗

High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel SequencingSemantic proximity Read ↗

A targeted next-generation sequencing panel for identification of clinically relevant mutation profiles in solid tumoursSemantic proximity Read ↗

Targeted therapy according to next generation sequencing-based panel sequencingSemantic proximity Read ↗

Clinical impact of a cancer genomic profiling test using an in-house comprehensive targeted sequencing system.Semantic proximity Read ↗

Next-generation sequencing to guide cancer therapySemantic proximity Read ↗

Development and validation of an ultra-high sensitive next-generation sequencing assay for molecular diagnosis of clinical oncology.Semantic proximity Read ↗

Next-Generation Sequencing in Oncology—A Guiding Compass for Targeted Therapy and Emerging ApplicationsSemantic proximity Read ↗

A targeted next-generation sequencing assay detects a high frequency of therapeutically targetable alterations in primary and metastatic breast cancers: implications for clinical practice.Semantic proximity Read ↗

Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies.Semantic proximity Read ↗

Actionable mutational profiling in solid tumors using hybrid-capture-based next-generation sequencing in a real-world setting in Spain.Semantic proximity Read ↗

Next-generation sequencing and molecular therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.