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Article

The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.

Cancer research - 15 Oct 2010

Dews Michael, Fox Jamie L, Hultine Stacy, Sundaram Prema, Wang Wenge, Liu Yingqiu Y, Furth Emma, Enders Gregory H, El-Deiry Wafik, Schelter Janell M, Cleary Michele A, Thomas-Tikhonenko Andrei

Abstract excerpt

c-Myc stimulates angiogenesis in tumors through mechanisms that remain incompletely understood. Recent work indicates that c-Myc upregulates the miR-17∼92 microRNA cluster and downregulates the angiogenesis inhibitor thrombospondin-1, along with other members of the thrombospondin type 1 repeat s...

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Identifiers

PMID: 20940405
DOI: 10.1158/0008-5472.CAN-10-2412
PMCID: PMC3007123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20940405-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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