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Article

A stem-cell based bioassay to critically assess the pathology of dysfunctional neuromuscular junctions.

PloS one - 1 Jan 2014

Chipman Peter H, Zhang Ying, Rafuse Victor F

Abstract excerpt

Pluripotent stem cells can be directed to differentiate into motor neurons and assessed for functionality in vitro. An emerging application of this technique is to model genetically inherited diseases in differentiated motor neurons and to screen for new therapeutic targets. The neuromuscular junction (NMJ) is essential to the functionality of motor neurons and its dysfunction is a primary hallmark of motor...

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Identifiers

PMID: 24626225
DOI: 10.1371/journal.pone.0091643
PMCID: PMC3953473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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