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Article

Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy.

Cell stem cell - 8 Apr 2011

Marteyn Antoine, Maury Yves, Gauthier Morgane M, Lecuyer Camille, Vernet Remi, Denis Jérôme A, Pietu Geneviève, Peschanski Marc, Martinat Cécile

Abstract excerpt

Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting a variety of organs, including the central nervous system. By using neuronal progeny derived from human embryonic stem cells carrying the causal DM1 mutation, we have identified an early developmental defect in genes involved in neurite formation and the establishment of neuromuscular connections. Differential gene expression profiling and...

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Identifiers

PMID: 21458401
DOI: 10.1016/j.stem.2011.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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