Article
Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study.
Human genetics - 1 Feb 2013
Guo Yan-Fang, Zhang Li-Shu, Liu Yong-Jun, Hu Hong-Gang, Li Jian, Tian Qing, Yu Ping, Zhang Feng, Yang Tie-Lin, Guo Yan, Peng Xiang-Lei, Dai Meng, Chen Wei, Deng Hong-Wen
Abstract excerpt
Bone and muscle, two major tissue types of musculoskeletal system, have strong genetic determination. Abnormality in bone and/or muscle may cause musculoskeletal diseases such as osteoporosis and sarcopenia. Bone size phenotypes (BSPs), such as hip bone size (HBS), appendicular bone size (ABS), are genetically correlated with body lean mass (mainly muscle mass). However, the specific genes shared by these...
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