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Article

MTHFR functional genetic variation and methotrexate treatment response in rheumatoid arthritis: a meta-analysis.

Pharmacogenomics - 1 Mar 2014

Morgan Michael D, Al-Shaarawy Nashwa, Martin Steve, Robinson James I, Twigg Sarah, Magdy Awadalla A, Omar Aziza Sayed, Ghattas Maivel H, Emery Paul, Barrett Jennifer H, Morgan Ann W

Abstract excerpt

AIM: To date, functional MTHFR SNPs have been tested for their impact on low-dose methotrexate (MTX) response in small rheumatoid arthritis (RA) cohorts. We sought to test their effect in the single largest cohort studied to date, and undertook a meta-analysis utilizing stringent study inclusion criteria. MATERIALS & METHODS: RA patients treated with MTX monotherapy from the Yorkshire Early Arthritis Register...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Identifiers

PMID: 24624914
DOI: 10.2217/pgs.13.235

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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