Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis.

doi:10.1038/s41598-018-25634-y

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Article

Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis.

Scientific reports - 9 May 2018

López-Rodríguez Rosario, Ferreiro-Iglesias Aida, Lima Aurea, Bernardes Miguel, Pawlik Andrzej, Paradowska-Gorycka Agnieszka, Świerkot Jerzy, Slezak Ryszard, Dolžan Vita, González-Álvaro Isidoro, Narváez Javier, Cáliz Rafael, Pérez-Pampín Eva, Mera-Varela Antonio, Vidal-Bralo Laura, Acuña Ochoa José Gorgonio, Conde Carmen, Gómez-Reino Juan J, González Antonio

Abstract excerpt

About 70 genetic studies have already addressed the need of biomarkers to predict the response of patients with rheumatoid arthritis (RA) to methotrexate (MTX) treatment. However, no genetic biomarker has yet been sufficiently validated. Here, we aimed to replicate a selection of 25 SNPs in the largest collection of patients up to date, which consisted of 915 patients treated with MTX. The change in disease...

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PMID: 29743634
DOI: 10.1038/s41598-018-25634-y
PMCID: PMC5943457

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MTRR

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