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Article

Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis.

Pharmacogenomics - 1 Feb 2010

Kooloos Wouter M, Wessels Judith Am, van der Straaten Tahar, Allaart Cornelia F, Huizinga Tom Wj, Guchelaar Henk-Jan

Abstract excerpt

AIMS: Clinical response to methotrexate (MTX) treatment differs among rheumatoid arthritis patients. Genetic variation can partly account for this phenomenon. In this study, functional polymorphisms in genes related to the mechanism of action of MTX or immunopathogenesis of rheumatoid arthritis w...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20136356
DOI: 10.2217/pgs.09.139

Genes

ABCB1
TLR4
DHFR
IMPDH2
ITPA
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20136356-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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