Article
Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Sept 2006
Hughes L B, Beasley T M, Patel H, Tiwari H K, Morgan S L, Baggott J E, Saag K G, McNicholl J, Moreland L W, Alarcón G S, Bridges S L
Abstract excerpt
BACKGROUND: The anti-folate drug methotrexate (MTX) is commonly used to treat rheumatoid arthritis. OBJECTIVE: To determine the allele frequencies of five common coding single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene in African-Americans and Caucasians with rheumatoid arthritis and controls to assess whether there are differences in allele frequencies among these...
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