Article
MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms.
The pharmacogenomics journal - 1 Apr 2013
Owen S A, Lunt M, Bowes J, Hider S L, Bruce I N, Thomson W, Barton A
Abstract excerpt
Association of two key variants mapping to the MTHFR gene (C677T (rs1801133) and A1298C (rs1801131)) with response to methotrexate (MTX) remains controversial. We investigated these and other markers spanning the gene as predictors of MTX efficacy and adverse events in a UK rheumatoid arthritis (...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.