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Article

Macrophages are required for cell death and tissue remodeling in the developing mouse eye.

Cell - 13 Aug 1993

Lang R A, Bishop J M

Abstract excerpt

To identify and characterize tissue remodeling processes mediated by macrophages, we have generated transgenic mice in which diphtheria toxin is expressed from a macrophage-specific transgene. Expression of the transgene disrupts subsets of mature macrophages in both the eye and the peritoneal cavity and results in the persistence of two normally transient ocular tissues, the hyaloid vasculature and the pupillary...

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Identifiers

PMID: 8348612
DOI: 10.1016/0092-8674(93)80047-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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