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Article

Attenuation of Human Enterovirus 71 High-Replication-Fidelity Variants in AG129 Mice

13 Mar 2014

Abstract excerpt

UNLABELLED: In a screen for ribavirin resistance, a novel high-fidelity variant of human enterovirus 71 (EV71) with the single amino acid change L123F in its RNA-dependent RNA polymerase (RdRp or 3D) was identified. Based on the crystal structure of EV71 RdRp, L123 locates at the entrance of the RNA template binding channel, which might form a fidelity checkpoint. EV71 RdRp-L123F variants generated less progeny...

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PMID: 24623423
DOI: 10.1128/jvi.00289-14

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