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Article

A reverse genetics system for enterovirus D68 using human RNA polymerase I.

Virus genes - 1 Aug 2018

Pan Minglei, Gao Shuai, Zhou Zhenwei, Zhang Keke, Liu Sihua, Wang Zhiyun, Wang Tao

Abstract excerpt

Human enterovirus D68 (EV-D68) is a highly contagious virus, which causes respiratory tract infections. However, no effective vaccines are currently available for controlling EV-D68 infection. Here, we developed a reverse genetics system to recover EV-D68 minireplicons and infectious EV-D68 from transfected plasmids using the RNA polymerase I (Pol I) promoter. The EV-D68 minireplicons contained the luciferase...

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Identifiers

PMID: 29777445
DOI: 10.1007/s11262-018-1570-3

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