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Impact of Genomic Variations Found in Enterovirus A71 Virus Population on Viral Properties and Disease Severity.

Journal of medical virology - 1 Feb 2026

Lai Yi-Wen, Cheng Dayna, Huang Sheng-Wen, Chu Justin Jang Hann, Yeh Ming-Te, Chang Chuan-Fa, Chen Cheng-Yao, Wang Jen-Ren

Abstract excerpt

Since 1998, enterovirus A71 (EV-A71) has caused several outbreaks in Taiwan with hundreds of severe cases and deaths. EV-A71 exhibits a high genome mutation rate, resulting in a diverse viral population, called quasispecies. However, the consequence of variations found in quasispecies with EV-A71 viral virulence remains elusive. In this study, we aim to analyze the viral genomes of severe and mild clinical...

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PMID: 41586444
DOI: 10.1002/jmv.70814

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DLD

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