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Article

Mutation in enterovirus 71 nonstructural protein 3A increases genome replication fidelity and exhibits attenuated virulence in mice.

Journal of virology - 23 Oct 2025

Yu Fang, Xiong Dongyan, Zhong Yao, Zhang Qiu-Yan, Deng Cheng-Lin, Zhang Zhe-Rui, Wang Chang, Qiu Yang, Ye Han-Qing, Gong Peng, Zhang Bo

Abstract excerpt

Increasing numbers of studies have highlighted the important implications of the replication fidelity of RNA viruses for virus replication, pathogenesis, and the development of antiviral drugs and live-attenuated vaccines. However, most of the research has focused on viral polymerase, and little information is available about the potential role of other viral replicase proteins. Here, we demonstrated that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40960318
DOI: 10.1128/jvi.01207-25
PMCID: PMC12548465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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