Article
B cells with aberrant activation of Notch1 signaling promote Treg and Th2 cell-dominant T-cell responses via IL-33.
Blood advances - 25 Sept 2018
Arima Hiroshi, Nishikori Momoko, Otsuka Yasuyuki, Kishimoto Wataru, Izumi Kiyotaka, Yasuda Koubun, Yoshimoto Tomohiro, Takaori-Kondo Akifumi
Abstract excerpt
The Notch-signaling pathway in a variety of mature B-cell neoplasms is often activated by gene alterations, but its role remains unclear. Here, we show that B cells harboring dysregulated activation of Notch1 signaling have an immunomodulatory effect on T cells by amplifying regulatory T (Treg) and T helper 2 (Th2) cell responses in an interleukin-33 (IL-33)-dependent manner. A conditional mouse model, in which...
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