Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of Retronectin-Mediated T-Cell Activation on Expansion and Phenotype of CD19-Specific Chimeric Antigen Receptor T Cells.

Human gene therapy - 1 Oct 2018

Stock Sophia, Hoffmann Jean-Marc, Schubert Maria-Luisa, Wang Lei, Wang Sanmei, Gong Wenjie, Neuber Brigitte, Gern Ulrike, Schmitt Anita, Müller-Tidow Carsten, Dreger Peter, Schmitt Michael, Sellner Leopold

Abstract excerpt

Enhanced in vivo expansion, long-term persistence of chimeric antigen receptor T (CART) cells, and efficient tumor eradication through these cells are linked to the proportion of less-differentiated cells in the CART cell product. Retronectin is well established as an adjuvant for improved retroviral transduction, while its property to enrich less-differentiated T cells is less known. In order to increase these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Fibronectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy, Adoptive

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Receptors, Antigen, T-Cell

Share to Retroviridae

Share to T-Lymphocyte Subsets

Share to Transduction, Genetic

Source

Identifiers

PMID: 30024314
DOI: 10.1089/hum.2017.237

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of Retronectin-Mediated T-Cell Activation on Expansion and Phenotype of CD19-Specific Chimeric Antigen Receptor T Cells.PMID 30024314Read ↗

Effects of polybrene and retronectin as transduction enhancers on the development and phenotypic characteristics of VHH-based CD19-redirected CAR T cells: a comparative investigation.Semantic proximity Read ↗

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndromeSemantic proximity Read ↗

Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotypeSemantic proximity Read ↗

In Vivo Generation of CAR T Cells Selectively in Human CD4+ LymphocytesSemantic proximity Read ↗

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid TumorsSemantic proximity Read ↗

Common Trajectories of Highly Effective CD19-Specific CAR T Cells Identified by Endogenous T-cell Receptor LineagesSemantic proximity Read ↗

Media evaluation for production and expansion of anti-CD19 chimeric antigen receptor T cells.Semantic proximity Read ↗

Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo.Semantic proximity Read ↗

CD19-directed CAR T-cell therapy in B-cell NHLSemantic proximity Read ↗

Phenotypic Composition of Commercial Anti-CD19 CAR T Cells Affects In Vivo Expansion and Disease Response in Patients with Large B-cell Lymphoma.Semantic proximity Read ↗

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearanceSemantic proximity Read ↗

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral VectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.