Article
Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications
1 Jan 2022
Abstract excerpt
Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. Telomeric DNA damage response induced by some cancer treatments can persist for months, possibly accounting for long-term sequelae of cancer treatments....
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