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Identification of cellular senescence-specific genes by comparative transcriptomics

22 Aug 2016

Abstract excerpt

Cellular senescence is defined as permanent cell cycle arrest induced by various stresses. Although the p53 transcriptional activity is essential for senescence induction, the downstream genes that are crucial for senescence remain unsolved. Here, by using a developed experimental system in which cellular senescence or apoptosis is induced preferentially by altering concentration of etoposide, a DNA-damaging...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 27545311
DOI: 10.1038/srep31758

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