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Article

Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78

23 Apr 2014

Abstract excerpt

Glucose-regulated protein 78 (GRP78), the most abundant and well-characterized glucose-regulated protein, is a major stress-inducible chaperone localized to the endoplasmic reticulum (ER). The purpose of the present study was to investigate the mechanisms of GRP78 involved in the senescence sensitivity of ovarian cancer cells to cisplatin. In the present study, we found that the chemotherapy-sensitive ovarian...

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PMID: 24756776
DOI: 10.3892/or.2014.3147

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