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Article

Phospho-Bcl-xL(Ser62) influences spindle assembly and chromosome segregation during mitosis.

Cell cycle (Georgetown, Tex.) - 1 Jan 2014

Wang Jianfang, Beauchemin Myriam, Bertrand Richard

Abstract excerpt

Functional analysis of a series of phosphorylation mutants reveals that Bcl-xL(Ser62Ala) influences cell entry into anaphase and mitotic exit in taxol-exposed cells compared with cells expressing wild-type Bcl-xL or a series of other phosphorylation mutants, an effect that appears to be independent of its anti-apoptotic activity. During normal mitosis progression, Bcl-xL(Ser62) is strongly phosphorylated by PLK1...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24621501
DOI: 10.4161/cc.28293
PMCID: PMC4014433

Genes

PLK1
MAPK14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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