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Article

Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death

3 Oct 2013

Abstract excerpt

Microtubule inhibiting agents (MIAs) characteristically induce phosphorylation of the major anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2 and Bcl-xL, and although this leads to Mcl-1 degradation, the role of Bcl-2/Bcl-xL phosphorylation in mitotic death has remained controversial. This is in part due to variation in MIA sensitivity among cancer cell lines, the dependency of cell fate on drug concentration and...

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PMID: 24091677
DOI: 10.1038/cddis.2013.360

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