Article
Anti-inflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jun 2014
Kusunoki Hiroshi, Taniyama Yoshiaki, Otsu Rei, Rakugi Hiromi, Morishita Ryuichi
Abstract excerpt
The paracrine loop involving inflammatory cytokines between adipocytes and macrophages establishes a vicious cycle that aggravates pro-inflammatory changes in adipose tissue. The serum level of hepatocyte growth factor (HGF) is increased in metabolic syndrome, but whether HGF is beneficial or detrimental in inflammatory conditions is unclear. We previously reported that HGF has strong anti-inflammatory effects....
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