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Therapeutic potential of macrophage colony-stimulating factor in chronic liver disease

16 Feb 2022

Abstract excerpt

Resident and recruited macrophages control the development and proliferation of the liver. We have previously shown in multiple species that treatment with a macrophage colony stimulating factor (CSF1)-Fc fusion protein initiated hepatocyte proliferation and promoted repair in models of acute hepatic injury in mice. Here, we investigated the impact of CSF1-Fc on resolution of advanced fibrosis and liver...

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PMID: 35169835
DOI: 10.1242/dmm.049387

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