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Article

Severe thrombocytopenia in a patient with inosine triphosphatase (ITPA)-CC genotype caused by pegylated interferon (IFN)-α-2a with ribavirin therapy: a case report.

BMC research notes - 12 Mar 2014

Jiang Weimin, Hidaka Hisashi, Nakazawa Takahide, Kitagawa Hiroyuki, Koizumi Wasaburo

Abstract excerpt

BACKGROUND: Pegylated interferon combined with ribavirin treatment is an effective therapy for chronic hepatitis C viral infection. However, pegylated interferon combined with ribavirin is associated with various adverse reactions. Severe thrombocytopenia is a life-threatening side effect of interferon therapy that can lead to bleeding. It is generally understood that the inosine triphosphatase-CC genotype does...

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Source

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Identifiers

PMID: 24621321
DOI: 10.1186/1756-0500-7-141
PMCID: PMC3995698

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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