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Article

Increase in platelet count based on inosine triphosphatase genotype during interferon beta plus ribavirin combination therapy.

Journal of gastroenterology and hepatology - 1 Sept 2012

Nomura Hideyuki, Miyagi Yugo, Tanimoto Hironori, Yamashita Nobuyuki, Ito Kiyoaki, Masaki Naohiko, Mizokami Masashi

Abstract excerpt

BACKGROUND AND AIM: The inosine triphosphatase (ITPA) genotype is associated with ribavirin-induced anemia and pegylated interferon α (PEG IFN-α)-induced platelet reduction during PEG IFN-α plus ribavirin combination therapy. Natural IFN-β plus ribavirin therapy is associated with increases in platelet counts during treatment. We investigated decreases in platelet counts according to ITPA genotype during natural...

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Source

Identifiers

PMID: 22554247
DOI: 10.1111/j.1440-1746.2012.07171.x

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increase in platelet count based on inosine triphosphatase genotype during interferon beta plus ribavirin combination therapy.PMID 22554247Read ↗

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