IL28B genetic variation and cytomegalovirus-specific T-cell immunity in allogeneic stem cell transplant recipients.

doi:10.1002/jmv.24676

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Article

IL28B genetic variation and cytomegalovirus-specific T-cell immunity in allogeneic stem cell transplant recipients.

Journal of medical virology - 1 Apr 2017

Corrales Isabel, Solano Carlos, Amat Paula, Giménez Estela, de la Cámara Rafael, Nieto José, López Javier, García-Noblejas Ana, Piñana José Luis, Navarro David

Abstract excerpt

A single nucleotide polymorphism (SNP), 3 kbp upstream of the IL28B gene (rs12979860; C/T), has been shown to influence the dynamics of cytomegalovirus (CMV) replication in allogeneic stem cell transplant recipients (Allo-SCT). We investigated whether this SNP had any effect on the dynamics of CMV-specific T-cell immunity in these patients. CMV pp65/IE-1 IFN-γ CD8+ and CD4+ T cells were enumerated by flow...

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PMID: 27591738
DOI: 10.1002/jmv.24676

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