Article
Genome Report-A Genome Sequence Analysis of the RB51 Strain of Brucella abortus in the Context of Its Vaccine Properties.
G3 (Bethesda, Md.) - 9 Apr 2020
Bricker Betsy, Goonesekere Nalin, Bayles Darrell, Alt David, Olsen Steven, Vrentas Catherine
Abstract excerpt
The RB51 vaccine strain of Brucella abortus, which confers safe and effective protection of cattle from B. abortus infection, was originally generated via serial passage of B. abortus 2308 to generate spontaneous, attenuating mutations. While some of these mutations have been previously characterized, such as an insertional mutation in the wboA gene that contributes to the rough phenotype of the strain, a...
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