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Article

Systematic screen of chemotherapeutics in Drosophila stem cell tumors

10 Mar 2014

Abstract excerpt

Here we report the development of an in vivo system to study the interaction of stem cells with drugs using a tumor model in the adult Drosophila intestine. Strikingly, we find that some Food and Drug Administration-approved chemotherapeutics that can inhibit the growth of Drosophila tumor stem cells can paradoxically promote the hyperproliferation of their wild-type counterparts. These results reveal an...

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PMID: 24616500
DOI: 10.1073/pnas.1401160111

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