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Article

Methotrexate negatively acts on inflammatory responses triggered in Drosophila larva with hyperactive JAK/STAT pathway.

Developmental and comparative immunology - 1 Oct 2021

Yadav Ravi Kant, Gautam Dushyant Kumar, Muj Chukhu, Gajula Balija Madhu Babu, Paddibhatla Indira

Abstract excerpt

Drosophila is a valuable paradigm for studying tumorigenesis and cancer. Mutations causing hematopoietic aberrations and melanotic-blood-tumors found in Drosophila mutants are vastly studied. Clear understanding about the blood cells, signaling pathways and the tissues affected during hematopoietic tumor formation provide an opportunity to delineate the effects of cancer therapeutics. Using this simple...

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PMID: 34107277
DOI: 10.1016/j.dci.2021.104161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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