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Article

TolC-dependent modulation of host cell death by the Francisella tularensis live vaccine strain.

Infection and immunity - 1 May 2014

Doyle Christopher R, Pan Ji-An, Mena Patricio, Zong Wei-Xing, Thanassi David G

Abstract excerpt

Francisella tularensis is a facultative intracellular, Gram-negative pathogen and the causative agent of tularemia. We previously identified TolC as a virulence factor of the F. tularensis live vaccine strain (LVS) and demonstrated that a ΔtolC mutant exhibits increased cytotoxicity toward host cells and elicits increased proinflammatory responses compared to those of the wild-type (WT) strain. TolC is the outer...

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Share to Bacterial Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24614652
DOI: 10.1128/IAI.00044-14
PMCID: PMC3993420

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