Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence.

Proceedings of the National Academy of Sciences of the United States of America - 22 Aug 2006

Gil Horacio, Platz Gabrielle J, Forestal Colin A, Monfett Michael, Bakshi Chandra Shekhar, Sellati Timothy J, Furie Martha B, Benach Jorge L, Thanassi David G

Abstract excerpt

The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia. Interest in this zoonotic pathogen has increased due to its classification as a category A agent of bioterrorism, but little is known about the molecular mechanisms underlying its virulence, and especially what secretion systems and virulence factors are present. In this study, we characterized two genes in the F. tularensis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Outer Membrane Proteins
Share to Bacterial Vaccines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Francisella tularensis

Share to Gene Deletion

Share to Macrophages

Share to Mice, Inbred C3H

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 16908853
DOI: 10.1073/pnas.0602582103
PMCID: PMC1568944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence.PMID 16908853Read ↗

Characterization of a Unique Outer Membrane Protein Required for Oxidative Stress Resistance and Virulence of Francisella tularensis.Semantic proximity Read ↗

TolC-dependent modulation of host cell death by the Francisella tularensis live vaccine strain.Semantic proximity Read ↗

The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system.Semantic proximity Read ↗

Outer membrane vesicle-associated lipase FtlA enhances cellular invasion and virulence in Francisella tularensis LVS.Semantic proximity Read ↗

Genetics and genetic manipulation in Francisella tularensis.Semantic proximity Read ↗

Uncovering the components of the Francisella tularensis virulence stealth strategy.Semantic proximity Read ↗

Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis.Semantic proximity Read ↗

Single-copy chromosomal integration systems for Francisella tularensis.Semantic proximity Read ↗

Genetic diversity within the genus Francisella as revealed by comparative analyses of the genomes of two North American isolates from environmental sources.Semantic proximity Read ↗

The complete genome sequence of Francisella tularensis, the causative agent of tularemia.Semantic proximity Read ↗

IglG and IglI of the Francisella Pathogenicity Island Are Important Virulence Determinants of Francisella tularensis LVSSemantic proximity Read ↗

Mutations of Francisella novicida that alter the mechanism of its phagocytosis by murine macrophages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.