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Article

The Francisella tularensis LVS ΔpdpC mutant exhibits a unique phenotype during intracellular infection.

BMC microbiology - 29 Jan 2013

Lindgren Marie, Bröms Jeanette E, Meyer Lena, Golovliov Igor, Sjöstedt Anders

Abstract excerpt

BACKGROUND: A prerequisite for the virulence of the facultative intracellular bacterium Francisella tularensis is effective intramacrophage proliferation, which is preceded by phagosomal escape into the cytosol, and ultimately leads to host cell death. Many components essential for the intracellular life cycle are encoded by a gene cluster, the Francisella pathogenicity island (FPI), constituting a type VI...

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Identifiers

PMID: 23356941
DOI: 10.1186/1471-2180-13-20
PMCID: PMC3562505

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