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Article

Bacterial lipoproteins and other factors released by Francisella tularensis modulate human neutrophil lifespan: Effects of a TLR1 SNP on apoptosis inhibition.

Cellular microbiology - 1 Feb 2018

Kinkead Lauren C, Whitmore Laura C, McCracken Jenna M, Fletcher Joshua R, Ketelsen Brandi B, Kaufman Justin W, Jones Bradley D, Weiss David S, Barker Jason H, Allen Lee-Ann H

Abstract excerpt

Francisella tularensis infects several cell types including neutrophils, and aberrant neutrophil accumulation contributes to tissue destruction during tularaemia. We demonstrated previously that F. tularensis strains Schu S4 and live vaccine strain markedly delay human neutrophil apoptosis and thereby prolong cell lifespan, but the bacterial factors that mediate this aspect of virulence are undefined. Herein, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29063667
DOI: 10.1111/cmi.12795
PMCID: PMC5764820

Genes

TLR1
TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Bacterial lipoproteins and other factors released by Francisella tularensis modulate human neutrophil lifespan: Effects of a TLR1 SNP on apoptosis inhibition.PMID 29063667Read ↗

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