Occurrence and distribution of infection-specific PrP in tissues of clinical scrapie cases and cull sheep from scrapie-affected farms in Shetland.

doi:10.1053/jcpa.2002.0592

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Article

Occurrence and distribution of infection-specific PrP in tissues of clinical scrapie cases and cull sheep from scrapie-affected farms in Shetland.

Journal of comparative pathology - 1 Nov 2002

Jeffrey M, Begara-McGorum I, Clark S, Martin S, Clark J, Chaplin M, González L

Abstract excerpt

The prion protein (PrP) genotypes of all cull sheep originating from four scrapie-affected farms in Shetland in 1998-1999 were determined and a representative sample of the different genotypes was selected for necropsy. Samples of brain and selected viscera were removed from 159 such sheep aged 2-11 years. These samples were examined immunohistochemically and by Western blotting for infection-specific forms of...

Topics

Animals
Blotting, Western
Central Nervous System
Disease Outbreaks
Genetic Predisposition to Disease
Genotype
Immunoenzyme Techniques
Lymphoid Tissue
Prions
Scrapie
Sheep
United Kingdom

Source

Open in PubMed

Identifiers

PMID: 12443734
DOI: 10.1053/jcpa.2002.0592

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