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Article

Mitochondrial DNA variants influence mitochondrial bioenergetics in Drosophila melanogaster.

Mitochondrion - 1 Jul 2012

Correa C C, Aw W C, Melvin R G, Pichaud N, Ballard J W O

Abstract excerpt

The influence of mitochondrial DNA (mtDNA) mutations on human disease has been extensively studied, but the impact of mutations within the adaptive range is debated. We studied males from lines of Drosophila melanogaster that have a highly standardized nuclear genome but different mtDNA, at two ages. We measured mitochondrial respiration on permeabilized muscle fibers, hydrogen peroxide production of isolated...

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Identifiers

PMID: 22735574
DOI: 10.1016/j.mito.2012.06.005

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