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Article

The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection.

Retrovirology - 11 Mar 2014

Tsai Lily, Tasovski Ivan, Leda Ana Rachel, Chin Mario P S, Cheng-Mayer Cecilia

Abstract excerpt

BACKGROUND: Severe genetic bottleneck occurs during HIV-1 sexual transmission whereby most infections are initiated by a single transmitted/founder (T/F) virus. Similar observations had been made in nonhuman primates exposed mucosally to SIV/SHIV. We previously reported variable clinical outcome in rhesus macaques inoculated intravaginally (ivg) with a high dose of R5 SHIVSF162P3N. Given the potential...

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Source

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Identifiers

PMID: 24612462
DOI: 10.1186/1742-4690-11-22
PMCID: PMC3975242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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