Article
Mucosal transmission of pathogenic CXCR4-utilizing SHIVSF33A variants in rhesus macaques.
Virology - 15 Aug 1998
Harouse J M, Tan R C, Gettie A, Dailey P, Marx P A, Luciw P A, Cheng-Mayer C
Abstract excerpt
Infection of macaques with chimeric simian/human immunodeficiency virus (SHIV) expressing the envelope protein of HIV-1 provides a model system for studying HIV-1 infection in humans. To this end, four rhesus macaques (Macaca mulatta) were given a single intravaginal (IVAG) inoculation of cell-fr...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- Cells, Cultured
- Chimera
- DNA, Viral
- Female
- Gene Products, env
- Genes, env
- Genetic Variation
- HIV
- Humans
- Lymphocytes
- Macaca mulatta
- Nucleic Acid Heteroduplexes
- Polymerase Chain Reaction
- Receptors, CXCR4
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus