Article
Mucosal transmission of pathogenic CXCR4-utilizing SHIVSF33A variants in rhesus macaques.
Virology - 15 Aug 1998
Harouse J M, Tan R C, Gettie A, Dailey P, Marx P A, Luciw P A, Cheng-Mayer C
Abstract excerpt
Infection of macaques with chimeric simian/human immunodeficiency virus (SHIV) expressing the envelope protein of HIV-1 provides a model system for studying HIV-1 infection in humans. To this end, four rhesus macaques (Macaca mulatta) were given a single intravaginal (IVAG) inoculation of cell-free SHIVSF33A and longitudinal samples of peripheral blood and lymph nodes were analyzed for viremia, antigenemia, and...
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